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Article

Phenotypic and molecular changes in nodule-in-nodule hepatocellular carcinoma with pathogenetic implications.

Histopathology - 1 Oct 2018

Rudini Noemi, Novello Chiara, Destro Annarita, Riboldi Elena, Donadon Matteo, Viganò Luca, Morenghi Emanuela, Roncalli Massimo, Di Tommaso Luca

Abstract excerpt

AIMS: Nodule-in-nodule (N/N) hepatocellular carcinoma (HCC) is a convincing proof of multistep hepatocarcinogenesis. In this lesion, an inner HCC develops within an outer, more differentiated, tumour, which can be rapidly taken over by the former so that N/N HCC is rarely detected. METHODS AND RESULTS: Ten resected N/N HCCs arising in cirrhotic background and characterized: (i) as outer lesions by early (n = 3)...

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Identifiers

PMID: 29791027
DOI: 10.1111/his.13659

Genes

TERT
GPC3

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