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Article

Morphophenotypic changes in human multistep hepatocarcinogenesis with translational implications.

Journal of hepatology - 1 Jan 2016

Sciarra Amedeo, Di Tommaso Luca, Nakano Masayuki, Destro Annarita, Torzilli Guido, Donadon Matteo, Maggioni Marco, Bosari Silvano, Bulfamante Gaetano, Matsuda Masanori, Fujii Hideki, Ichikawa Tomoaki, Morisaka Hiroyuki, Sano Katsuhiro, Ichikawa Shintaro, Roncalli Massimo

Abstract excerpt

BACKGROUND & AIMS: Human hepatocarcinogenesis in cirrhosis is thought to be multistep and characterized by a spectrum of nodular lesions, ranging from low to high grade dysplastic nodules (LGDN and HGDN) to early and progressed hepatocellular carcinoma (eHCC and pHCC). The aim of this study was to investigate the morphophenotypical changes of this sequence and their potential translational significance. METHODS:...

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PMID: 26343958
DOI: 10.1016/j.jhep.2015.08.031

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GPC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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