Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as a evidence for multistage progression.

doi:10.1016/0304-3835(94)90319-0

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Article

Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as a evidence for multistage progression.

Cancer letters - 15 Aug 1994

Oda T, Tsuda H, Sakamoto M, Hirohashi S

Abstract excerpt

The p53 gene was analysed for mutation in three macro- and micro-scopically different areas of a nodule-in-nodule hepatocellular carcinoma (HCC). Two inner nodules revealed distinct mutations while the surrounding early HCC lesion was negative for mutation. This case clearly demonstrated that the...

Topics

Carcinoma, Hepatocellular
Genes, p53
Humans
Liver Neoplasms
Male
Middle Aged
Mutation
Precancerous Conditions

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