Article
Humoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes.
Med (New York, N.Y.) - 14 Feb 2025
Terroba-Navajas Paula, Spatola Marianna, Chuquisana Omar, Joubert Bastien, de Vries Juna M, Dik Andre, Marmolejo Laura, Jönsson Friederike, Lauc Gordan, Kovac Stjepana, Prüss Harald, Wiendl Heinz, Titulaer Maarten J, Honnorat Jérôme, Lünemann Jan D
Abstract excerpt
BACKGROUND: Immunoglobulin (Ig) G4 auto-antibodies (Abs) against contactin-associated protein-like 2 (Caspr2), a transmembrane cell adhesion protein expressed in the central and peripheral nervous system, are found in patients with a broad spectrum of neurological symptoms. While the adoptive transfer of Caspr2-specific IgG induces brain pathology in susceptible rodents, the mechanisms by which Caspr2-Abs mediate...
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