Prolactin rs1341239 T allele may have protective role against the brick tea type skeletal fluorosis.

doi:10.1371/journal.pone.0171011

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Article

Prolactin rs1341239 T allele may have protective role against the brick tea type skeletal fluorosis.

PloS one - 1 Jan 2017

Li Bing-Yun, Yang Yan-Mei, Liu Yang, Sun Jing, Ye Yan, Liu Xiao-Na, Liu Hong-Xu, Sun Zhen-Qi, Li Mang, Cui Jing, Sun Dian-Jun, Gao Yan-Hui

Abstract excerpt

OBJECTIVE: Prolactin (PRL) has been reported to be associated with increased bone turnover, and increased bone turnover is also a feature of skeletal fluorosis (SF). Autocrine/paracrine production of PRL is regulated by the extrapituitary promoter and a polymorphism in the extrapituitary PRL promoter at -1149 (rs1341239) is associated with disturbances of bone metabolism in other diseases. Here, we have...

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PMID: 28152004
DOI: 10.1371/journal.pone.0171011
PMCID: PMC5289533

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