Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

8 Jan 2019

Abstract excerpt

In humans and in mice the formation of nephrons during embryonic development reaches completion near the end of gestation, after which no new nephrons are formed. The final nephron complement can vary 10-fold, with reduced nephron number predisposing individuals to hypertension, renal, and cardiovascular diseases in later life. While the heterochronic genes lin28 and let-7 are well-established regulators of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Renal and related cancers
Share to Birth, Development, and Health
Share to Pregnancy and preeclampsia studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30635573
DOI: 10.1038/s41467-018-08127-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesisPMID 30635573Read ↗

Bmp7 drives proximal tubule expansion and determines nephron number in the developing kidneySemantic proximity Read ↗

Advances in understanding vertebrate nephrogenesisSemantic proximity Read ↗

LIN28-mediated gene regulatory loops synchronize developmental transitions throughout organogenesisSemantic proximity Read ↗

FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons.Semantic proximity Read ↗

Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron PatterningSemantic proximity Read ↗

Nephron progenitor maintenance is controlled through FGFs and Sprouty1 InteractionSemantic proximity Read ↗

Neonatal nephron loss during active nephrogenesis results in altered expression of renal developmental genes and markers of kidney injurySemantic proximity Read ↗

Hamartin regulates cessation of mouse nephrogenesis independently of MtorSemantic proximity Read ↗

Conserved and Divergent Features of Human and Mouse Kidney OrganogenesisSemantic proximity Read ↗

Small non-coding RNA expression in developing mouse nephron progenitor cellsSemantic proximity Read ↗

Kidney Nephron DeterminationSemantic proximity Read ↗

Roles and regulation of bone morphogenetic protein-7 in kidney development and diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.