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Article

p53-Autophagy-Metastasis Link

18 May 2018

Abstract excerpt

The tumor suppressor p53 as the "guardian of the genome" plays an essential role in numerous signaling pathways that control the cell cycle, cell death and in maintaining the integrity of the human genome. p53, depending on the intracellular localization, contributes to the regulation of various cell death pathways, including apoptosis, autophagy and necroptosis. Accumulated evidence suggests that this function...

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PMID: 29783720
DOI: 10.3390/cancers10050148

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