Article
A univariate perspective of multivariate genome-wide association analysis.
Genetic epidemiology - 1 Jul 2018
Guo Xiaobo, Zhu Junxian, Fan Qiao, He Mingguang, Wang Xueqin, Zhang Heping
Abstract excerpt
Multiple correlated phenotypes are frequently collected in genome-wide association studies (GWASs), and a systematic, simultaneous analysis of multiple phenotypes can integrate the signals from single phenotypes, therefore increasing the power of detecting genetic signals. However, fundamental questions remain open, including the conditions and reasons under which the multivariate analysis is beneficial, how a...
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