Article
Analyze multivariate phenotypes in genetic association studies by combining univariate association tests.
Genetic epidemiology - 1 Jul 2010
Yang Qiong, Wu Hongsheng, Guo Chao-Yu, Fox Caroline S
Abstract excerpt
Multivariate phenotypes are frequently encountered in genome-wide association studies (GWAS). Such phenotypes contain more information than univariate phenotypes, but how to best exploit the information to increase the chance of detecting genetic variant of pleiotropic effect is not always clear. Moreover, when multivariate phenotypes contain a mixture of quantitative and qualitative measures, limited methods are...
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