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Article

DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2020

Vyas Monika, Hechtman Jaclyn F, Zhang Yanming, Benayed Ryma, Yavas Aslihan, Askan Gokce, Shia Jinru, Klimstra David S, Basturk Olca

Abstract excerpt

Recently discovered DNAJB1-PRKACA oncogenic fusions have been considered diagnostic for fibrolamellar hepatocellular carcinoma. In this study, we describe six pancreatobiliary neoplasms with PRKACA fusions, five of which harbor the DNAJB1-PRKACA fusion. All neoplasms were subjected to a hybridization capture-based next-generation sequencing assay (MSK-IMPACT), which enables the identification of sequence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31676785
DOI: 10.1038/s41379-019-0398-2
PMCID: PMC7125037

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