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Case Report: BAP1 Mutation and RAD21 Amplification as Predictive Biomarkers to PARP Inhibitor in Metastatic Intrahepatic Cholangiocarcinoma

27 Nov 2020

Abstract excerpt

INTRODUCTION: Intrahepatic cholangiocarcinoma (ICC) is a rare hepatobiliary cancer characterized by a poor prognosis and a limited response to conventional therapies. Currently chemotherapy is the only therapeutic option for patients with Stage IV ICC. Due to the poor response rate, there is an urgent need to identify novel molecular targets to develop novel effective therapies. Precision oncology tests utilizing...

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Cholangiocarcinoma and Gallbladder Cancer Studies
Liver Diseases and Immunity
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33330039
DOI: 10.3389/fonc.2020.567289

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