Article
Organic anion transporting polypeptide (OATP)-mediated transport of coproporphyrins I and III.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jan 2016
Bednarczyk Dallas, Boiselle Carri
Abstract excerpt
1. Organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 are polyspecific transporters that mediate the transport of organic acids into hepatocytes. Inactivating mutations of both OATP1B1 and OATP1B3 alleles lead to Rotor syndrome, a disease characterized by coproporphyrinuria, an elevated urinary excretion of coproporphyrins I and III. It was hypothesized that transport of coproporphyrins I and III was...
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