Article
A new method of identifying glioblastoma subtypes and creation of corresponding animal models.
Oncogene - 1 Aug 2018
Zhou Xia, Li Gonghua, An Sanqi, Li Wen-Xing, Yang Huihui, Guo Yicheng, Dai Zhi, Dai Shaoxing, Zheng Junjuan, Huang Jingfei, Iavarone Antonio, Zhao Xudong
Abstract excerpt
Glioblastoma (GBM) accounts for up to 50% of brain parenchymal tumors. It is the most malignant type of brain cancer with very poor survival and limited remedies. Cancer subtyping is important for cancer research and therapy. Here, we report a new subtyping method for GBM based on the genetic alterations of CDKN2A and TP53 genes. CDKN2A and TP53 are the most frequently mutated genes with mutation rates of 60 and...
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