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Article

A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications.

Nature communications - 16 May 2018

Winkler Thomas W, Günther Felix, Höllerer Simon, Zimmermann Martina, Loos Ruth Jf, Kutalik Zoltán, Heid Iris M

Abstract excerpt

The problem of the genetics of related phenotypes is often addressed by analyzing adjusted-model traits, but such traits warrant cautious interpretation. Here, we adopt a joint view of adiposity traits in ~322,154 subjects (GIANT consortium). We classify 159 signals associated with body mass index (BMI), waist-to-hip ratio (WHR), or WHR adjusted for BMI (WHRadjBMI) at P < 5 × 10-8, into four classes based on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29769528
DOI: 10.1038/s41467-018-04124-9
PMCID: PMC5956079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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