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Article

Loss of sonic hedgehog gene leads to muscle development disorder and megaesophagus in mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2018

Jia Xueting, Min Li, Zhu Shengtao, Zhang Shutian, Huang Xiaofeng

Abstract excerpt

Sonic hedgehog ( Shh) is crucial for organogenesis in the foregut. This study investigated the function of Shh at the late-gestational stage; during which, the esophagus continues to differentiate. We established cytokeratin 14 ( CK14)-Cre;Shhfl/fl mice in which the down-regulation of Shh in the epithelium occurred at approximately the same time as esophageal muscle conversion. Hematoxylin and eosin and...

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PMID: 29768039
DOI: 10.1096/fj.201701581R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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