Article
High rates of variation in HLA-DQ2/DQ8 testing for coeliac disease: results from an RCPAQAP pilot program.
Journal of clinical pathology - 1 Oct 2018
Horan Martin Patrick, Chai Sze Yee, Munusamy Nalishia, Tay Kwang Hong, Wienholt Louise, Tye-Din Jason A, Daveson James, Varney Michael, Badrick Tony
Abstract excerpt
AIM: Coeliac disease(CD) is a highly prevalent, gluten-dependent, autoimmune enteropathy. While the diagnosis is based on serological and histological criteria, genotyping of the human leucocyte antigens (HLA) DQ2 and DQ8 has been shown to have substantial clinical utility, especially in excluding the diagnosis in patients who do not carry either antigen. As a result, HLA genotyping is now being performed by more...
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