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Article

Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance.

Cancer communications (London, England) - 9 May 2018

Xu Yunhua, Zhang Feifei, Pan Xiaoqing, Wang Guan, Zhu Lei, Zhang Jie, Wen Danyi, Lu Shun

Abstract excerpt

BACKGROUND: Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions show dramatic responses to specific tyrosine kinase inhibitors (TKIs); however, after 10-12 months, secondary mutations arise that confer resistance. We generated a murine xenograft model using patient-derived NSCLC cells isolated from the pleural fluid of two...

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Source

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Identifiers

PMID: 29764505
DOI: 10.1186/s40880-018-0284-1
PMCID: PMC5993147

Genes

ALK
EGFR
BRAF
EML4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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