Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.

doi:10.1016/j.ccell.2018.04.004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.

Cancer cell - 14 May 2018

Mackay Alan, Burford Anna, Molinari Valeria, Jones David T W, Izquierdo Elisa, Brouwer-Visser Jurriaan, Giangaspero Felice, Haberler Christine, Pietsch Torsten, Jacques Thomas S, Figarella-Branger Dominique, Rodriguez Daniel, Morgan Paul S, Raman Pichai, Waanders Angela J, Resnick Adam C, Massimino Maura, Garrè Maria Luisa, Smith Helen, Capper David, Pfister Stefan M, Würdinger Thomas, Tam Rachel, Garcia Josep, Thakur Meghna Das, Vassal Gilles, Grill Jacques, Jaspan Tim, Varlet Pascale, Jones Chris

Abstract excerpt

The HERBY trial was a phase II open-label, randomized, multicenter trial evaluating bevacizumab (BEV) in addition to temozolomide/radiotherapy in patients with newly diagnosed non-brainstem high-grade glioma (HGG) between the ages of 3 and 18 years. We carried out comprehensive molecular analysis integrated with pathology, radiology, and immune profiling. In post-hoc subgroup analysis, hypermutator tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bevacizumab

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Chemoradiotherapy

Share to DNA Polymerase III

Share to Glioma

Share to Neoplasm Grading

Share to Neurofibromin 1

Share to Temozolomide

Source

Open in PubMed Open full text

Identifiers

PMID: 29763623
DOI: 10.1016/j.ccell.2018.04.004
PMCID: PMC5956280

Genes

POLD1
POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.PMID 29763623Read ↗

Radiological Evaluation of Newly Diagnosed Non-Brainstem Pediatric High-Grade Glioma in the HERBY Phase II Trial.Semantic proximity Read ↗

Pediatric Hemispheric High-Grade Gliomas and H3.3-G34 Mutation: A Review of the Literature on Biological Features and New Therapeutic Strategies.Semantic proximity Read ↗

MRI and Molecular Characterization of Pediatric High-Grade Midline Thalamic Gliomas: The HERBY Phase II Trial.Semantic proximity Read ↗

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.Semantic proximity Read ↗

Comprehensive molecular characterization of pediatric treatment-induced high-grade glioma: A distinct entity despite disparate etiologies with defining molecular characteristics and potential therapeutic targetsSemantic proximity Read ↗

Advances in the biology and treatment of pediatric central nervous system tumors.Semantic proximity Read ↗

Pediatric High Grade Glioma Resources From the Children’s Brain Tumor Tissue Consortium (CBTTC) and Pediatric Brain Tumor Atlas (PBTA)Semantic proximity Read ↗

High-grade gliomas in adolescents and young adults highlight histomolecular differences from their adult and pediatric counterparts.Semantic proximity Read ↗

The Molecular, Neurological, and Clinical Features of Diffuse Intrinsic Pontine GliomaSemantic proximity Read ↗

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma.Semantic proximity Read ↗

Multi-institution analysis of tumor mutational burden and outcomes in pediatric CNS tumor patientsSemantic proximity Read ↗

Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.