Article
PD-1 Expression in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Large B-cell Richter Transformation (DLBCL-RT): A Characteristic Feature of DLBCL-RT and Potential Surrogate Marker for Clonal Relatedness.
The American journal of surgical pathology - 1 Jul 2018
He Rong, Ding Wei, Viswanatha David S, Chen Dong, Shi Min, Van Dyke Daniel, Tian Shulan, Dao Linda N, Parikh Sameer A, Shanafelt Tait D, Call Timothy G, Ansell Stephen M, Leis Jose F, Mai Ming, Hanson Curtis A, Rech Karen L
Abstract excerpt
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a low-grade B-cell neoplasm and ∼2% to 9% patients develop an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (Richter transformation, DLBCL-RT). Programmed death-1 (PD-1) pathway plays a crucial role in tumor host immunity evasion and its blockade has emerged as an effective anti-cancer immunotherapy. PD-L1 and PD-1 expression...
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