Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis.

doi:10.1158/1078-0432.CCR-24-1327

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Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2024

Starrett Gabriel J, Baikie Brittany C, Stoff Benjamin K, Grossniklaus Hans E, Van Buren Inga, Berry Elizabeth G, Novoa Roberto A, Rieger Kerri E, Sarin Kavita Y, Lynch Charles F, Royer Michael C, Piaskowski Mary L, Brownell Isaac, Chu Emily Y, Godse Rama, Chen Suephy C, Yu Kelly J, Goldstein Alisa M, Engels Eric A, Sargen Michael R

Abstract excerpt

PURPOSE: Sebaceous carcinoma is the third most common nonkeratinocyte skin cancer in the United States with 1,000 cases per year. The clinicopathologic features of sebaceous carcinoma and benign sebaceous neoplasms (adenomas, sebaceomas) can overlap, highlighting the need for molecular biomarkers to improve classification. This study describes the genomic and transcriptomic landscape of sebaceous neoplasms in...

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PMID: 39287419
DOI: 10.1158/1078-0432.CCR-24-1327
PMCID: PMC11530307

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