Article
The molecular cartography of malignant and benign sebaceous tumours.
Nature communications - 19 Dec 2025
Ferreira I, Rueda O M, van der Weyden L, Sahni S, Cast O, Wong K, Del Castillo Velasco-Herrera M, Caldwell H, Boccacino J M, Alegbe T, Mehta I, Gunjur A, Gupta P, Harle V, Koga K, Matzusaki I, Fujimoto M, Wiedemeyer K, Stratigos A, Oniscu A, Wang K, Ruppin E, Demetter P, Frayling I M, Arends M J, Brenn T, Adams D J
Abstract excerpt
Sebaceous tumours (STs) are rare skin appendage tumours and include benign sebaceous adenoma (SA) and sebaceoma (SM), malignant extra-ocular sebaceous carcinoma (SC-E) and peri-ocular sebaceous carcinoma (SC-O). Here, an extensive worldwide collection of 286 tumours is deeply characterised, revealing a propensity to develop in the context of a high tumour mutational burden (except in SC-O) which is most...
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