Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pregnancy affects nevirapine pharmacokinetics: evidence from a CYP2B6 genotype-guided observational study.

Pharmacogenetics and genomics - 1 Aug 2016

Olagunju Adeniyi, Bolaji Oluseye, Neary Megan, Back David, Khoo Saye, Owen Andrew

Abstract excerpt

OBJECTIVES: Previous studies on nevirapine pharmacokinetics during pregnancy reported contradictory findings. METHODS: The magnitude of pregnancy-induced changes in nevirapine pharmacokinetics was investigated in a genotype-guided study preceded by a pharmacogenetic association study of six genes involved in its disposition. RESULTS: CYP2B6 516 G>T and 983 T>C were associated independently with plasma nevirapine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Constitutive Androstane Receptor

Share to Cytochrome P-450 CYP2B6

Share to Nevirapine

Share to Postpartum Period

Share to Pregnancy

Share to Tissue Distribution

Source

Identifiers

PMID: 27195527
DOI: 10.1097/FPC.0000000000000227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pregnancy affects nevirapine pharmacokinetics: evidence from a CYP2B6 genotype-guided observational study.PMID 27195527Read ↗

Pharmacogenetics of pregnancy-induced changes in efavirenz pharmacokinetics.Semantic proximity Read ↗

Associations between CYP2B6 polymorphisms and pharmacokinetics after a single dose of nevirapine or efavirenz in African americans.Semantic proximity Read ↗

Effect of cytochrome P450 2D6 genotype on maternal paroxetine plasma concentrations during pregnancy.Semantic proximity Read ↗

Potential effect of pharmacogenetics on maternal, fetal and infant antiretroviral drug exposure during pregnancy and breastfeeding.Semantic proximity Read ↗

Precision dosing-based optimisation of paroxetine during pregnancy for poor and ultrarapid CYP2D6 metabolisers: a virtual clinical trial pharmacokinetics study.Semantic proximity Read ↗

When special populations intersect with drug-drug interactions: Application of physiologically-based pharmacokinetic modeling in pregnant populations.Semantic proximity Read ↗

Integration of population pharmacokinetics and pharmacogenetics: an aid to optimal nevirapine dose selection in HIV-infected individualsSemantic proximity Read ↗

Pharmacogenetics of nevirapine excretion into breast milk and infants' exposure through breast milk versus postexposure prophylaxis.Semantic proximity Read ↗

Exploration of CYP450 and drug transporter genotypes and correlations with nevirapine exposure in Malawians.Semantic proximity Read ↗

Adverse events associated with nevirapine use in pregnancySemantic proximity Read ↗

Pharmacogenetics of Efavirenz Exposure in Cervicovaginal Fluid during Pregnancy and Postpartum.Semantic proximity Read ↗

Cytochrome P450 2B6 516G-->T is associated with plasma concentrations of nevirapine at both 200 mg twice daily and 400 mg once daily in an ethnically diverse population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.