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Article

Pharmacogenetic interactions between antiretroviral drugs and vaginally administered hormonal contraceptives.

Pharmacogenetics and genomics - 1 Apr 2020

Haas David W, Cramer Yoninah S, Godfrey Catherine, Rosenkranz Susan L, Aweeka Francesca, Berzins Baiba, Coombs Robert, Coughlin Kristine, Moran Laura E, Gingrich David, Zorrilla Carmen D, Baker Paxton, Cohn Susan E, Scarsi Kimberly K

Abstract excerpt

OBJECTIVE: In AIDS Clinical Trials Group study A5316, efavirenz lowered plasma concentrations of etonogestrel and ethinyl estradiol, given as a vaginal ring, while atazanavir/ritonavir increased etonogestrel and lowered ethinyl estradiol concentrations. We characterized the pharmacogenetics of these interactions. METHODS: In A5316, women with HIV enrolled into control (no antiretrovirals), efavirenz [600 mg daily...

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Identifiers

PMID: 32106141
DOI: 10.1097/FPC.0000000000000396
PMCID: PMC7398416

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