Article

Discovery of a potent anti-Zika virus benzamide series targeting the viral protein NS4B

2025-10-09

Abstract excerpt

1. <h4>ABSTRACT</h4> Zika virus (ZIKV), a member of the Flaviviridae family, causes significant public health concerns through congenital Zika syndrome and Guillain-Barré syndrome, yet no effective anti-ZIKV drugs or vaccines are available. To address this critical need, we conducted phenotypic, cytopathic effect-based, high-throughput screening followed by medicinal chemistry optimization and discovered novel b...

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Identifiers and source

Literature Corpus work: 91c2421d-9eca-5e83-8e92-9d7db155fdd6
DOI: 10.1101/2025.10.09.681361

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