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A systematic review and meta-analysis reveals pervasive effects of germline mitochondrial replacement on components of health.

Human reproduction update - 1 Sept 2018

Dobler Ralph, Dowling Damian K, Morrow Edward H, Reinhardt Klaus

Abstract excerpt

BACKGROUND: Mitochondrial replacement, a form of nuclear transfer, has been proposed as a germline therapy to prevent the transmission of mitochondrial diseases. Mitochondrial replacement therapy has been licensed for clinical application in the UK, and already carried out in other countries, but little is known about negative or unintended effects on the health of offspring born using this technique. OBJECTIVE...

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PMID: 29757366
DOI: 10.1093/humupd/dmy018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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