Article
Next-generation sequencing identifies novel single nucleotide polymorphisms in high-risk cutaneous squamous cell carcinoma: A pilot study.
Experimental dermatology - 1 Jul 2020
Lobl Marissa B, Hass Blake, Clarey Dillon, Higgins Shauna, Wysong Ashley
Abstract excerpt
BACKGROUND: Cutaneous squamous cell carcinoma (SCC) causes 1 million cases in the United States annually. There are germline single nucleotide polymorphisms (SNPs) that result in an increased risk of SCC and altered response to therapy. PREMISE: There may be biologically relevant SNPs not detected using traditional GWAS studies. HYPOTHESIS: There are clinically and biologically relevant SNPs in high-risk SCC that...
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