The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism

Abstract excerpt

Dear Editor, Japanese encephalitis (JE) is a mosquito-borne acute neurological infectious disease caused by the Japanese encephalitis virus (JEV). Globally, 68,000 cases of the disease are estimated each year, with a fatality rate of as high as 30% and with approximately 30%–50% of survivors suffering from severe neurological sequelae (WHO, 2015). Vaccination is the most economical and effective method for...