Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14

doi:10.1099/0022-1317-76-2-409

Article

Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14

1 Feb 1995

Abstract excerpt

To identify the molecular determinants for attenuation of wild-type Japanese encephalitis (JE) virus strain SA14, the RNA genome of wild-type strain SA14 and its attenuated vaccine virus SA14-2-8 were reverse transcribed, amplified by PCR and sequenced. Comparison of the nucleotide sequence of SA14-2-8 vaccine virus with virulent parent SA14 virus and with two other attenuated vaccine viruses derived from SA14...

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