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Article

Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2

2021-01-14

Abstract excerpt

<h4>ABSTRACT</h4> The live attenuated Japanese encephalitis virus vaccine SA14-14-2 demonstrated ≥ 95 % efficacy and is today the vaccine of choice against JEV globally. Relative to its parent strain SA14, SA14-14-2 carries 46 nucleotide and 24 amino acid alterations, with 8 of the latter located within the envelope glycoprotein. The vaccine strain also fails to synthesize the nonstructural protein NS1’ owing to...

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Literature Corpus work
2e8b30f9-b05d-5556-a515-5ab50d90e777
DOI
10.1101/2021.01.14.426643
Open publication

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Molecular mechanisms underlying attenuation of live attenuated Japanese encephalitis virus vaccine SA14-14-2DOI 10.1101/2021.01.14.426643
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