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Article

Identification and structural characterization of a histidinol phosphate phosphatase from Mycobacterium tuberculosis.

The Journal of biological chemistry - 29 Jun 2018

Jha Bhavya, Kumar Deepak, Sharma Arun, Dwivedy Abhisek, Singh Ramandeep, Biswal Bichitra Kumar

Abstract excerpt

The absence of a histidine biosynthesis pathway in humans, coupled with histidine essentiality for survival of the important human pathogen Mycobacterium tuberculosis (Mtb), underscores the importance of the bacterial enzymes of this pathway as major antituberculosis drug targets. However, the identity of the mycobacterial enzyme that functions as the histidinol phosphate phosphatase (HolPase) of this pathway...

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Identifiers

PMID: 29752410
DOI: 10.1074/jbc.RA118.002299
PMCID: PMC6028948

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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