Article
Structural and mechanistic characterization of L-histidinol phosphate phosphatase from the polymerase and histidinol phosphatase family of proteins.
Biochemistry - 12 Feb 2013
Ghodge Swapnil V, Fedorov Alexander A, Fedorov Elena V, Hillerich Brandan, Seidel Ronald, Almo Steven C, Raushel Frank M
Abstract excerpt
L-Histidinol phosphate phosphatase (HPP) catalyzes the hydrolysis of L-histidinol phosphate to L-histidinol and inorganic phosphate, the penultimate step in the biosynthesis of L-histidine. HPP from the polymerase and histidinol phosphatase (PHP) family of proteins possesses a trinuclear active site and a distorted (β/α)(7)-barrel protein fold. This group of enzymes is closely related to the amidohydrolase...
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