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Article

Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections

11 May 2018

Abstract excerpt

BACKGROUND: A variety of neurological disorders including neurodegenerative diseases and infection by neurotropic viruses can cause structural and functional changes in the central nervous system (CNS), resulting in long-term neurological sequelae. An improved understanding of the pathogenesis of these disorders is important for developing efficacious interventions. Human induced pluripotent stem cells (hiPSCs)...

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PMID: 29751846
DOI: 10.1186/s13287-018-0881-6

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