Article
AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease.
Acta neuropathologica communications - 1 Feb 2017
Ip Chi Wang, Klaus Laura-Christin, Karikari Akua A, Visanji Naomi P, Brotchie Jonathan M, Lang Anthony E, Volkmann Jens, Koprich James B
Abstract excerpt
α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson's disease (PD). AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey substantia nigra (SN) induces degeneration of nigral dopaminergic neurons and decreases striatal dopamine and tyrosine hydroxylase (TH). Given certain advantages of the mouse, especially it being amendable to genetic manipulation, translating the...
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