Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution.

doi:10.1016/j.chom.2018.04.005

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution.

Cell host & microbe - 9 May 2018

Peretti Alberto, Geoghegan Eileen M, Pastrana Diana V, Smola Sigrun, Feld Pascal, Sauter Marlies, Lohse Stefan, Ramesh Mayur, Lim Efrem S, Wang David, Borgogna Cinzia, FitzGerald Peter C, Bliskovsky Valery, Starrett Gabriel J, Law Emily K, Harris Reuben S, Killian J Keith, Zhu Jack, Pineda Marbin, Meltzer Paul S, Boldorini Renzo, Gariglio Marisa, Buck Christopher B

Abstract excerpt

BK polyomavirus (BKV) frequently causes nephropathy (BKVN) in kidney transplant recipients (KTRs). BKV has also been implicated in the etiology of bladder and kidney cancers. We characterized BKV variants from two KTRs who developed BKVN followed by renal carcinoma. Both patients showed a swarm of BKV sequence variants encoding non-silent mutations in surface loops of the viral major capsid protein. The temporal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to APOBEC Deaminases

Share to BK Virus

Share to Cytidine Deaminase

Share to Cytosine Deaminase

Share to Kidney Diseases

Share to Polyomavirus Infections

Share to Tumor Virus Infections

Source

Open in PubMed Open full text

Identifiers

PMID: 29746834
DOI: 10.1016/j.chom.2018.04.005
PMCID: PMC5953553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of BK Polyomaviruses from Kidney Transplant Recipients Suggests a Role for APOBEC3 in Driving In-Host Virus Evolution.PMID 29746834Read ↗

BK Polyomavirus Genetic Diversity and Evolution in Kidney Transplant Recipients With Viral Nephropathy According to Whole Genome Sequencing.Semantic proximity Read ↗

Polyomavirus BK Genome Comparison Shows High Genetic Diversity in Kidney Transplant Recipients Three Months after Transplantation.Semantic proximity Read ↗

Time-dependent variations in BK polyomavirus genome from kidney transplant recipients with persistent viremiaSemantic proximity Read ↗

Persistent BK Polyomavirus Viruria is Associated with Accumulation of VP1 Mutations and Neutralization Escape.Semantic proximity Read ↗

BK Virus Infection in Transplant Recipients: An Overview and UpdateSemantic proximity Read ↗

BK polyomavirus—pathogen, paradigm and puzzleSemantic proximity Read ↗

Do BKPyV genomic features underlie clinical divergence between kidney and hematopoietic transplant recipients?Semantic proximity Read ↗

A diverse virome in kidney transplant patients contains multiple viral subtypes with distinct polymorphisms.Semantic proximity Read ↗

Next-generation sequencing shows marked rearrangements of BK polyomavirus that favor but are not required for polyomavirus-associated nephropathy.Semantic proximity Read ↗

Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by PolyomavirusesSemantic proximity Read ↗

Viral integration in BK polyomavirus-associated urothelial carcinoma in renal transplant recipients: multistage carcinogenesis revealed by next-generation virome capture sequencingSemantic proximity Read ↗

BK polyomavirus: latency, reactivation, diseases and tumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.