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Article

Next-generation sequencing shows marked rearrangements of BK polyomavirus that favor but are not required for polyomavirus-associated nephropathy.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jan 2020

Liimatainen Hanna, Weseslindtner Lukas, Strassl Robert, Aberle Stephan W, Bond Gregor, Auvinen Eeva

Abstract excerpt

BACKGROUND: BKPyV is associated with polyomavirus-associated nephropathy (PVAN), a major cause of graft rejection in kidney transplant recipients (KTRs). Mutations occur in the transcriptional control region (TCR) of BKPyV, but whether they are required for the development of PVAN is not completely understood. To this end, we characterized BKPyV TCRs from KTRs to assess whether TCR mutations are associated with...

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PMID: 31783265
DOI: 10.1016/j.jcv.2019.104215

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