Somatic clones heterozygous for recessive disease alleles of BMPR1A exhibit unexpected phenotypes in Drosophila.

Abstract excerpt

The majority of mutations studied in animal models are designated as recessive based on the absence of visible phenotypes in germline heterozygotes. Accordingly, genetic studies primarily rely on homozygous loss-of-function to determine gene requirements, and a conceptually-related 'two-hit model' remains the central paradigm in cancer genetics. Here we investigate pathogenesis due to somatic mutation in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Bone Morphogenetic Protein Receptors, Type I
• Share to Drosophila