Article
How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects.
PLoS genetics - 1 Nov 2017
Chandler Christopher H, Chari Sudarshan, Kowalski Alycia, Choi Lin, Tack David, DeNieu Michael, Pitchers William, Sonnenschein Anne, Marvin Leslie, Hummel Kristen, Marier Christian, Victory Andrew, Porter Cody, Mammel Anna, Holms Julie, Sivaratnam Gayatri, Dworkin Ian
Abstract excerpt
For a given gene, different mutations influence organismal phenotypes to varying degrees. However, the expressivity of these variants not only depends on the DNA lesion associated with the mutation, but also on factors including the genetic background and rearing environment. The degree to which these factors influence related alleles, genes, or pathways similarly, and whether similar developmental mechanisms...
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