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Article

Drosophila models of FOP provide mechanistic insight.

Bone - 1 Apr 2018

Le Viet, Anderson Edward, Akiyama Takuya, Wharton Kristi A

Abstract excerpt

Fibrodysplasia ossificans progressiva (FOP) is a rare bone disease characterized by episodic events of heterotopic ossification (HO). All cases of FOP have been attributed to mutations in the ACVR1 gene that render the encoded BMP type I ALK2 receptor hypersensitive, resulting in the activation of BMP signaling, at inappropriate times in inappropriate locations. The episodic or sporadic nature of HO associated...

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Source

Identifiers

PMID: 29128351
DOI: 10.1016/j.bone.2017.11.001

Genes

ACVR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Drosophila models of FOP provide mechanistic insight.PMID 29128351Read ↗

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