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Article

The BRAFV600E mutation maintains the aggressiveness of papillary thyroid cancers requiring downregulation of primary cilia.

Molecular and cellular endocrinology - 1 Feb 2024

Ma Cheng-Xu, Ma Xiao-Ni, Liu Jin-Jin, Guan Cong-Hui, Li Ying-Dong, Zhao Nan, Mauricio Dídac, Fu Song-Bo

Abstract excerpt

Although disorders of primary cilia (PCs) were first reported in human papillary thyroid cancer (PTC) tissues in 1987, their precise role in PTC remains unclear. PCs sense the thyroid follicle colloid environment and act as a cell signaling hub. The present study investigated whether PCs are needed for BRAFV600E-driven PTC. We assessed whether BRAFV600E protein expression correlates with papillary histological...

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Share to Carcinoma, Papillary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

Share to Thyroid Cancer, Papillary

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Source

Identifiers

PMID: 37989409
DOI: 10.1016/j.mce.2023.112113

Genes

PC
IFT88

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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