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High-throughput sequencing of the T cell receptor β gene identifies aggressive early-stage mycosis fungoides

9 May 2018

Abstract excerpt

gene, was an independent prognostic factor of both progression-free and overall survival in patients with CTCL and MF in particular. In early-stage patients, a TCF of >25% in the skin was a stronger predictor of progression than any other established prognostic factor (stage IB versus IA, presence of plaques, high blood lactate dehydrogenase concentration, large-cell transformation, or age). The TCF therefore may...

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PMID: 29743350
DOI: 10.1126/scitranslmed.aar5894

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