Article
Genomic Profile and Pathologic Features of Diffuse Large B-Cell Lymphoma Subtype of Methotrexate-associated Lymphoproliferative Disorder in Rheumatoid Arthritis Patients.
The American journal of surgical pathology - 1 Jul 2018
Carreras Joaquim, Yukie Kikuti Yara, Miyaoka Masashi, Hiraiwa Shinichiro, Tomita Sakura, Ikoma Haruka, Kondo Yusuke, Shiraiwa Sawako, Ando Kiyoshi, Sato Shinji, Suzuki Yasuo, Miura Ikuo, Roncador Giovanna, Nakamura Naoya
Abstract excerpt
Rheumatoid arthritis patients often develop the diffuse large B-cell lymphoma subtype of methotrexate-associated lymphoproliferative disorder (DLBCL). We characterized the genomic profile and pathologic characteristics of 20 biopsies using an integrative approach. DLBCL was associated with extranodal involvement, a high/high-intermediate international prognostic index in 53% of cases, and responded to MTX...
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