Article
Pharmacogenetic testing by polymorphic markers 681G>A and 636G>A CYP2C19 gene in patients with acute coronary syndrome and gastric ulcer in the Republic of Sakha (Yakutia).
Drug metabolism and personalized therapy - 27 Jun 2018
Fedorinov Denis S, Mirzaev Karin B, Ivashchenko Dmitriy V, Temirbulatov Ilyas I, Sychev Dmitriy A, Maksimova Nadezda R, Chertovskih Jana V, Popova Nyurguiana V, Tayurskaya Ksenia S, Rudykh Zoya A
Abstract excerpt
BACKGROUND: The focus of the study is to determine the prevalence of CYP2C19 alleles, associated with the risk of changes in the pharmacological response to clopidogrel and proton pump inhibitors in patients with acute coronary syndrome (ACS) and gastric ulcer from Russian and Yakut ethnic groups. METHODS: The research included 411 patients with ACS (143 Russians and 268 Yakuts) and 204 patients with...
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