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Article

Quantitative Prioritization of Tool Compounds for Phenotypic Screening.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Wang Yuan, Jenkins Jeremy L

Abstract excerpt

Phenotypic screens are increasingly utilized in drug discovery for multiple purposes such as lead and/or tool compound finding, and target discovery. Using potent and selective chemical tool compounds against well-defined targets in phenotypic screens can help elucidate biological processes modulating assay phenotypes. Unfortunately the identification of such tools from large heterogeneous bioactivity databases...

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PMID: 29736720
DOI: 10.1007/978-1-4939-7847-2_15

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