The limitations of small molecule and genetic screening in phenotypic drug discovery.

Abstract excerpt

Phenotypic screens carried out with functional genomics or small molecules have led to novel biological insights, revealed previously unknown targets for drug discovery programs, and provided starting points for the development of first-in-class therapies. Despite being valuable research tools, genetic and compound screening also have significant limitations. This perspective aims to shed a light on those...

Topics

• Drug Discovery
• Small Molecule Libraries
• Humans
• Phenotype
• Drug Evaluation, Preclinical
• Genetic Testing