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How Phenotypic Screening Influenced Drug Discovery: Lessons from Five Years of Practice.

Assay and drug development technologies - 1 Jan 2000

Haasen Dorothea, Schopfer Ulrich, Antczak Christophe, Guy Chantale, Fuchs Florian, Selzer Paul

Abstract excerpt

Since 2011, phenotypic screening has been a trend in the pharmaceutical industry as well as in academia. This renaissance was triggered by analyses that suggested that phenotypic screening is a superior strategy to discover first-in-class drugs. Despite these promises and considerable investments, pharmaceutical research organizations have encountered considerable challenges with the approach. Few success stories...

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PMID: 28800248
DOI: 10.1089/adt.2017.796

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