Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study.

doi:10.1155/2018/7564835

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Article

Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study.

Canadian journal of gastroenterology & hepatology - 1 Jan 2018

Vespasiani-Gentilucci Umberto, Dell'Unto Chiara, De Vincentis Antonio, Baiocchini Andrea, Delle Monache Marco, Cecere Roberto, Pellicelli Adriano Maria, Giannelli Valerio, Carotti Simone, Galati Giovanni, Gallo Paolo, Valentini Francesco, Del Nonno Franca, Rosati Davide, Morini Sergio, Antonelli-Incalzi Raffaele, Picardi Antonio

Abstract excerpt

Background & Aims: Identifying NAFLD patients at risk of progression is crucial to orient medical care and resources. We aimed to verify if the effects determined by different single nucleotide polymorphisms (SNPs) could add up to multiply the risk of NAFLD and NASH-cirrhosis. Methods: Three study populations, that is, patients diagnosed with NASH-cirrhosis or with noncirrhotic NAFLD and healthy controls, were...

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Identifiers

PMID: 29732362
DOI: 10.1155/2018/7564835
PMCID: PMC5872672

Genes

KLF6
LPIN1
PNPLA3
SOD2

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Source receipt: pubmed, retrieved 6 Sept 2026.

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