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Article

Atopic asthma after rhinovirus‐induced wheezing is associated with DNA methylation change in the SMAD 3 gene promoter

5 May 2018

Abstract excerpt

Children with rhinovirus-induced severe early wheezing have an increased risk of developing asthma later in life. The exact molecular mechanisms for this association are still mostly unknown. To identify potential changes in the transcriptional and epigenetic regulation in rhinovirus-associated atopic or nonatopic asthma, we analyzed a cohort of 5-year-old children (n = 45) according to the virus etiology of the...

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PMID: 29729188
DOI: 10.1111/all.13473

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