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Article

Rhinovirus infections change DNA methylation and mRNA expression in children with asthma

28 Nov 2018

Abstract excerpt

Human rhinovirus infection (HRVI) plays an important role in asthma exacerbations and is thought to be involved in asthma development during early childhood. We hypothesized that HRVI causes differential DNA methylation and subsequently differential mRNA expression in epithelial cells of children with asthma. Primary nasal epithelial cells from children with (n = 10) and without (n = 10) asthma were cultivated up...

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PMID: 30485264
DOI: 10.1371/journal.pone.0205275

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