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High-throughput screen identifies small molecule inhibitors targeting acetyltransferase activity of Mycobacterium tuberculosis GlmU.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2015

Rani Chitra, Mehra Rukmankesh, Sharma Rashmi, Chib Reena, Wazir Priya, Nargotra Amit, Khan Inshad Ali

Abstract excerpt

N-acetylglucosamine-1-phosphate uridyltransferase (GlmU) is a pivotal bifunctional enzyme, its N and C terminal domains catalyzes uridyltransferase and acetyltransferase activities, respectively. Final product of GlmU catalyzed reaction, uridine-diphospho-N-acetylglucosamine (UDP-GlcNAc), acts as sugar donor providing GlcNAc residues in the synthesis of peptidoglycan and a disaccharide linker...

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PMID: 26318557
DOI: 10.1016/j.tube.2015.06.003

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