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Article

Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas.

Molecular and cellular endocrinology - 15 Nov 2018

Bizzi Mariana Ferreira, Pinheiro Sergio Veloso Brant, Bolger Graeme B, Schweizer Junia Ribeiro de Oliveira Longo, Giannetti Alexandre V, Dang Mary N, Ribeiro-Oliveira Antonio, Korbonits Márta

Abstract excerpt

Type 4 phosphodiesterases (PDE4s) of the large PDE enzyme superfamily have unique specificity for cAMP and may, therefore, be relevant for somatotroph tumorigenesis. Somatotroph adenomas typically overexpress PDEs probably as part of a compensatory mechanism to reduce cAMP levels. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein, coded by a tumour suppressor gene mutated in a subgroup...

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Identifiers

PMID: 29729370
DOI: 10.1016/j.mce.2018.04.014

Genes

AIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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